BMC Complementary and Alternative Medicine. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. However, the long-term safety of consuming large amounts of peppermint leaf is unknown. Peppermint tea, which is made from peppermint leaves, appears to be safe.Little is known about whether it’s safe to use peppermint oil during pregnancy or while breastfeeding.Peppermint oil should not be applied to the face of infants or young children because serious side effects may occur if they inhale the menthol in the oil. Side effects of applying peppermint oil to the skin can include skin rashes and irritation.If enteric-coated peppermint oil capsules are taken at the same time as antacids, the coating can break down too quickly. Capsules containing peppermint oil are often enteric-coated to reduce the likelihood of heartburn.Rarely, peppermint oil can cause allergic reactions. Possible side effects of peppermint oil taken orally include heartburn, nausea, abdominal pain, and dry mouth.Peppermint oil has been safely used in many clinical trials.
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